IBD and Celiac Disease
Ulcerative colitis (UC) and Crohn's disease (CD) are the most common forms of inflammatory bowel diseases (IBD) in humans. These diseases are characterized by cycles of chronic relapses and remissions. These cycles are associated with chronic inflammation of the intestinal mucosa and an abnormal gut microflora. Celiac disease is caused by an immune response to the protein gluten. It is believed to affect 1 in 200 people in the modernized world, and results in a decreased ability of the body to absorb nutrients.
Boswellia and IBD
Boswellia is well known for its anti-inflammatory effects. Animal experiments have showed that boswellia modulates some components of the immune system, thereby reducing inflammation. In clinical trials, promising results were obtained in UC patients using boswellia. All parameters studied improved with boswellia supplementation. Furthermore, 82% of the patients treated with boswellia went into remission whereas only 75% of the patients receiving sulfasalazine (an anti-inflammatory drug used to treat UC) experienced a remission. Similar results have also been shown for patients with Crohn's disease. It is not surprising that according to the latest survey, 36% of German IBD patients surveyed use boswellia as part of their treatment protocol.
DPP IV for Inflammation & Auto-immunity
Over-activation of the immune system during an infection can drive the immune system into a state of autoimmunity, which leads to cellular damage and chronic inflammation. Autoimmunity can be promoted through the inappropriate activation of the immune system by certain proteins in the diet. This is the underlying mechanism behind celiac disease, where the immune system inappropriately targets the protein gluten. The problem can be aggravated by a lack of dipeptidyl peptidase IV (DPP-IV) enzyme activity in certain gastrointestinal conditions.
DPP-IV is an enzyme whose activity is required to break down proteins linked to the exacerbation of conditions such as IBD and celiac disease. DPP IV promotes a normal immune response and is important for the modulation of immune messengers that regulate immunity and inflammation. Low DPP-IV levels results in the accumulation of undigested protein fragments, which are thought to elicit an immune response that can inflame the lining of the gastrointestinal tract. Supplementation with DPP-IV enzymes prevents the activation of the immune system by breaking down dietary proteins like gluten before they activate an immune response - a significant benefit for those suffering from autoimmune disorders like IBD or celiac disease.
Research has shown that prolyl endopeptidases (PEPs) also help to break down gluten, reducing the occurrence of gluten induced intestinal inflammation. Currently the only treatment for celiac disease is life-long avoidance of wheat, rye, barley and other gluten containing foods. IBD Relief includes PEPs derived from the fungus Aspergillus niger (AN-PEP). AN-PEP is superior to other gluten-reducing enzymes because it remains active over a wide pH range, and is not destroyed by stomach acidity. Not only does AN-PEP work at stomach's natural pH, but it has been shown to degrade gluten proteins 60 times faster than other enzymes commonly used.
Vitamin D and autoimmune diseases
The evidence linking vitamin D and the prevalence of autoimmune diseases continues to grow. There is clear evidence that vitamin D is needed for the proper functioning of the immune system and especially for the maintenance of self tolerance. Vitamin D has been shown to inhibit the induction of auto-immune diseases such as systemic lupus erythematosus, type-1 diabetes and IBD. The vitamin D receptor also appears to have a critical role in the control and response of the colon to chemical injury.
Withania somnifera for Stress
There is significant psychological stress in dealing with any chronic disease. Chronic stress may lead to a breakdown in coping mechanisms and worsen the course of IBD. Withania somnifera is well known for its ability to enhance the body's response to stress. This traditional ayurvedic herb can also help support the immune system and liver function.
A Successful Combination
IBD Relief provides an innovative and effective combination of ingredients to help those with IBD or celiac disease to manage and prevent inflammation and exacerbation of the condition. The effectiveness of IBD Relief can be further enhanced if combined with additional Vitamin D3 supplementation as well as a complete probiotic supplement, like Clinical Biotics, to help normalize the intestinal flora.
Geier, M., Butler, R., Howarth, G. Inflammatory bowel disease: Current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics. International J of Food Microbiology, 115 (2007), pp1-11.
Gupta I, Parihar A, Malhotra P, Singh GB, Lüdtke R, Safayhi H, Ammon HP. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997 Jan;2(1):37-43.
Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R. Therapy of active Crohn disease with Boswellia serrata extract H 15. Z Gastroenterol. 2001 Jan;39(1):11-7.
Sedo A, Malik R. Dipeptidyl peptidase IV-like molecules: homologous proteins or homologous activities? Biochim Biophys Acta. 2001 Dec 17;1550(2):107-16. Review.
Tiruppathi C, Miyamoto Y, Ganapathy V, Leibach FH. Genetic evidence for role of DPP IV in intestinal hydrolysis and assimilation of prolyl peptides. Am J Physiol. 1993 Jul;265(1 Pt 1):G81-9.
Stepniak, D., et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. The American Physiological Society. [Online] http://www.the-aps.org/press/journal/06/13.htm 2006.
Froicu M, Cantorna MT. Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol. 2007 Mar 30;8:5.
Goodhand J, Rampton D. Psychological stress and coping in IBD. Gut. 2008 Oct;57(10):1345-7.
Archana R, Namasivayam A.Antistressor effect of Withania somnifera. J Ethnopharmacol 1999 Jan; 64(1): 91-3