Hours: Mon-Fri: 10am-6pm
Thu: 10am-7pm Sat: 10am-6pm  Sundays: Closed

Prostaphil 2 (AOR)

DISCUSSION: Prostaphil-2TM is defined pollen extract, which is not bee pollen, but a defined blend of water and fat-soluble extracts from specific pollens in characteristic ratios first crafted in Sweden. Research demonstrates defined pollen extract’s superior support for prostate health compared to saw palmetto and other common prostate herbals.enign prostatic hyperplasia (BPH) - the noncancerous swelling of the prostate gland, leading to discomfort, nocturia (the need to get up in the middle of the night for a trip to the bathroom), frequent and sudden urges to urinate even when the bladder is not full, intermittency (dribbling at the end of the urinary stream), and incomplete emptying of the bladder when urinating - affects nearly all men to some degree beginning in late middle age. Saw palmetto, along with stinging nettle, Pygeum africanum, beta-sitosterol, and a few other herbals, is reached for in health food stores across North America almost by reflex. And there is evidence that these botanicals improve the symptoms of BPH.However, these herbs don't address the fundamental problem: the actual increase in the volume of the prostate gland itself. Despite what you hear, clinical trials have repeatedly documented that saw palmetto has no effect on prostate volume. The German Commission E Monographs are careful to spell this out, if most supplement hawkers are not: saw palmetto "relieves only the symptoms associated with an enlarged prostate without reducing the enlargement." And it's the same with the others.Because of this, the Monograph for saw palmetto advises users to "Please consult a physician at regular intervals." The reason: even as their symptoms are relieved, saw palmetto allows the prostate to continue to grow, so that surgery may eventually become necessary. Indeed, experience with drugs which relieve BPH symptoms without addressing prostate volume (such as alpha 1 -adrenergic blockers (eg Hytrin® or Flomax®)) has shown that, lacking any warning symptoms, men often put off surgery for far too long, leading to concern that these treatments may actually increase the complications of BPH.By contrast, there is plenty of evidence that finasteride (Proscar®), the most famous drug therapy for BPH, can reduce prostate volume. Unfortunately, finasteride takes a long time to relieve symptoms, does not work with several classes of patients, is very expensive, and has significant side effects, including erectile dysfunction and loss of libido. Furthermore, despite long-standing hopes that this drug would reduce the risk of prostate cancer because of its ability to reduce levels of the cancer marker prostate-specific antigen (PSA), the first clinical trial to test this hypothesis has found that finasteride has pretty muddled results: it decreases the overall risk of prostate cancer - but increases the risk of the most aggressive, deadly forms of the disease.So men find themselves pinned on the horns of a serious dilemma: symptomatic improvement with no halt to the loss of prostate health, or a treatment which addresses the core problem, but causes problems of its own.The Real Prostate Health AlternativeDefined pollen extract is different. While still new to Canadians, defined pollen extract been used with success by two generations of European men. Defined pollen extract is not bee pollen. Bee pollen is a mixture of whatever pollens with which the insects happen to have come into contact. Defined pollen extract, by contrast, is a mixture of several specific pollen sources (primarily rye, but also including timothy grass, corn, hazel, sallow, aspen, oxye, and pine pollens). Also, bee pollen in its raw form is covered with a microscopic husk which prevents its full assimilation by humans; by contrast, defined pollen extract uses a precise process to isolate the key fractions from the pollen, incorporating a specific 20:1 ratio of lipid- and water-soluble components extracted under low-temperature conditions, bypassing the pollen's protective sheath.Proven in Controlled TrialsIn contrast to saw palmetto and the other standard prostate botanicals, four randomized, double-blind, controlled clinical trials have shown that defined pollen extract quickly improves prostate symptoms and reduces prostate volume. In one of these studies, sixty men with symptomatic BPH received either the pollen extract or placebo for six months. Sixty-nine percent of men receiving the pollen extract experienced improved overall symptoms, compared to less than a third of the placebo group. There were statistically significant differences in the number of incidences of nocturia, decreased leftover urine in the bladder after urination ("residual urine volume"). Compared to the placebo group, there were also more improvements reported by men receiving the pollen extract in hesitancy (inability to release urinary flow) and intermittency, but these results were not strong enough, in this small a group over this short a period, to be statistically meaningful.But most importantly, this study reported that men using defined pollen extract experience significant reductions in the volume of the prostate as measured by ultrasound. In fact, every trial of defined pollen extract in men with BPH, which has measured prostate volume, size, or weight has reported significant reductions in the gland.Proven More Effective than Other BotanicalsHow do these results stack up to the common prostate herbals? Very well, thank you. In a head-to-head trial against Tadenan® (the best-studied and most famous brand of Pygeum africanum in Europe), Dutkiewicz reported that 78% of the men in the pollen extract group experienced subjective improvements, versus "only" 55% of the Pygeum group. Another trial compared it with Paraprost. Significant improvements in residual urinary volume, flow rate, and (again, most importantly) prostatic weight were seen in the pollen extract group as compared to the Paraprost group; the lenth of time required to urinate was also better, although the improvement did not meet the statistical test of significe.The most impressive comparison is that with beta-sitosterol - both because beta-sitosterol is perhaps the most rigorously studied of all the common prostate health herbals, and because of the unique insight the trial yielded about the power of the pollen extract. The trial found that greater relief was experienced by men in the pollen extract group in their subjective symptoms, painful urination, and frequent urination, while the two groups demonstrated equal improvements in straining, urinary volume, residual volume, and intermittency.Also important was the fact that this trial was the first to measure the effect of these two supplements on levels of prostate-specific antigen (PSA - a marker used to detect prostate cancer) and prostatic acid phosphatase (PAP - an enzyme which is elevated in many prostatic dysfunctions). Men supplementing with defined pollen extract experienced significant reductions in both PAP and PSA, whereas no significant change was reported in the beta-sitosterol group. In still another trial, defined pollen extract demonstrated its superiority to the amino acid mixture Paraprost.Other Prostate Health ConcernsBPH, of course, is not the only prostate disorder that men may face. Others include chronic prostatitis (CP) and prostatodynia. Because the symptoms of these disorders sound similar, many men with CP or prostatodynia mistakenly self-medicate with saw palmetto. And unfortunately, the relative ignorance of many mainstream MDs about the herbal pharmacy leads them to give the go-ahead for this useless course of action - useless, because there is no evidence that saw palmetto or the other common herbals for BPH are helpful for these conditions. By contrast, several open trials have found that defined pollen extract is helpful in chronic prostatitis and prostatodynia.Hope for Prostate CancerAn even graver prostate health concern for many men is prostate cancer. Autopsy studies show that 15 to 30% of men over 50, and 60 to 70 percent of men over the age of 80, have latent, undiagnosed prostate cancer. There has been exciting progress made in the last few years in the discovery of natural ways of reducing the risk of prostate cancer, including successful double-blind, placebo-controlled trials with selenium, and extremely promising preliminary result with the carotenoid lycopene.While it's far too soon to be sure, preliminary evidence suggests the possibility that defined pollen extract may yet prove to be a safe, natural herb to help the fight against the second greatest cause of cancer death in men. Much of this evidence comes from studies in isolated prostate cancer cells, which have found that fractions of the pollen extract selectively inhibit the growth of human prostate cancer cells.Another hint that defined pollen extract may protect men from this scourge is the finding - from the controlled clinical trial mentioned earlier - that defined pollen extract lowers PSA, considered a marker of prostate cancer risk. As the results with finasteride have shown, the reduction in PSA does not itself guarantee a corresponding reduction in risk; however, the results are certainly promising, and many men are taking these preliminary results into account when considering which prostate botanical to use.How Does it Work?The mechanism of action of defined pollen extract remains elusive. Molecular, experimental,and clinical studies suggest that defined pollen extract may reduce inflammation and balance the muscle tone of the urethra and bladder - effects which might help to explain some of the extract's effects on the symptoms of BPH.But the exact method by which the defined pollen extract exerts its most exciting influence on the prostate - namely, its ability to reduce the actual volume of the prostate - remains unknown. Proscar,® the most successful drug therapy for BPH, reduces prostate volume by inhibiting 5-a-reductase (5AR), the enzyme which converts testosterone into the much more prostate-stimulating dihydrotestosterone (DHT). In test-tube studies, defined pollen extracts do inhibit 5AR; however, they also inhibit the less-known hydroxysteroid oxioreductase (HSORred) enzymes, which convert DHT to the less-stimulating 3-alpha- and 3-beta-diol. In other words, the pollen extract directly decreases both the synthesis and the clearance of DHT. What the end result of this would be is unclear, but the net effect on DHT activity levels in the prostate could very well be zero. Clearly, more studies are needed, but direct inhibition of DHT may not be a key mechanism of the pollen's activity.Further studies are clearly needed. All we can say with certainty, from existing evidence, is that defined pollen extract works, relieving the symptoms of BPH and reducing prostate volume. How it works is a question for continued scientific investigations.Not Just for the Prostate... And Not Just for Men!Most people taking the pollen extract are using it for the health of their prostate, which is by far the best-backed usage for this botanical. Yet there are hints in the literature of a broad range of other applications which get much less attention. One such property is detoxification and hepatoprotection. Animal studies have found that the defined pollen extract provides protection against a variety of liver toxins, including as ammonium fluoride, paracetamol, organic solvents, allyl alcohol, the deadly carbon tetrachloride, cadmium, and galctosamine.Finally, although we emphasize that the evidence is purely anecdotal, in some parts of the world more women buy defined pollen extracts than men, because they have found that the pollen extract helps with urinary incontinence - which, although unproven by clinical trials, is consistent with the improved bladder and urethral smooth muscle tone balance, which the pollen extract is known to afford. Funding is presently being sought to run a controlled trial on this application.The Future of Prostate CareProscar® and other drugs for BPH are effective, but come with side effects and a cost which make drug therapy unattractive to many men. The natural alternatives commonly found on health food store shelves may help relieve symptoms, but do not ultimately address the underlying cause. Defined pollen extract has been effectively helping European men with many prostate health problems for decades now, and is proven to do what no other herbal can: shrink swollen prostates. As the pollen itself is golden, so defined pollen extract may open up a golden age for safe, natural therapy for the most personal of male health concerns.ReferencesBuck AC, Cox R, Rees RW, Ebeling L, John A. Treatment of outflow tract obstruction due to benign prostatic hyperplasia with the pollen extract, cernilton. A double-blind, placebo-controlled study. Br J Urol. 1990 Oct; 66(4): 398-404.Dutkiewicz S. Usefulness of Cernilton in the treatment of benign prostatic hyperplasia. Int Urol Nephrol. 1996; 28(1): 49-53.Maekawa M, Kishimoto T, Yasumoto R, Wada S, Harada T, Ohara T, Okajima E, Hirao Y, Ohzono S, Shimada K, et al. Clinical evaluation of cernilton on benign prostatic hypertrophy - a multiple center double-blind study with Paraprost. Hinyokika Kiyo. 1990 Apr; 36(4): 495-516.Ebeling L. Therapeutic results of defined pollen-extract in patients with chronic prostatis or BPH accompanied by chronic prostatitis. In , Schmiedt E, Alken JE, Bauer HW (eds). Therapy of Prostatitis. Munich: Zuckerschwerdt Verlag, 1986; 154-60.Brauer H. The treatment of benign prostatic hyperplasia with phytopharmata: a comparative study of cernilton vs. beta-sitosterol. Therapiewoche. 1986; 36: 1686-96.Yasumoto R, Kawanishi H, Tsujino T, Tsujita M, Nishisaka N, Horii A, Kishimoto T. Clinical evaluation of long-term treatment using cernitin pollen extract in patients with benign prostatic hyperplasia. Clin Ther. 1995 Jan-Feb; 17(1): 82-7.Becker H, Ebeling L. Phytotherapy of BPH with cernilton N - results of a controlled prospective study. Urologe (B) 1991; 31: 113-6.Roberts KP, Iyer RA, Prasad G, Liu LT, Lind RE, Hanna PE. Cyclic hydroxamic acid inhibitors of prostate cancer cell growth: selectivity and structure activity relationships. Prostate. 1998 Feb 1; 34(2): 92-9.Jaton JC, Roulin K, Rose K, Sirotnak FM, Lewenstein A, Brunner G, Fankhauser CP, Burger U. The secalosides, novel tumor cell growth inhibitory glycosides from a pollen extract. J Nat Prod. 1997 Apr; 60(4): 356-60.Zhang X, Habib FK, Ross M, Burger U, Lewenstein A, Rose K, Jaton JC. Isolation and characterization of a cyclic hydroxamic acid from a pollen extract, which inhibits cancerous cell growth in vitro. J Med Chem. 1995 Feb 17; 38(4): 735-8.Blumenthal M (ed). The Complete German Commission E Monographs. Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council, 1998.The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.Copyright © 2005, Advanced Orthomolecular Research